Which genetic disorder results in excessive deposition of glycogen in the liver?

The correct answer is Glycogen Storage Disease, which is characterized by a group of inherited disorders that lead to the excessive accumulation of glycogen in various tissues, particularly in the liver and muscles. This accumulation occurs due to a deficiency in one of the enzymes responsible for glycogen metabolism. Depending on the specific type of Glycogen Storage Disease, symptoms can arise during infancy or later in life and can include hepatomegaly (enlarged liver), hypoglycemia (low blood sugar), and muscle weakness. The excess glycogen can cause cellular damage in the liver, resulting in a range of potential complications.

In contrast, Hemochromatosis involves iron overload rather than glycogen accumulation and affects iron metabolism leading to iron deposition in various organs, particularly the liver. Wilson's Disease is associated with copper accumulation due to a defect in copper metabolism, while Non-Alcoholic Fatty Liver Disease involves the excessive buildup of fat in the liver, generally related to metabolic conditions, rather than glycogen. Thus, Glycogen Storage Disease specifically aligns with the condition described in the question, focusing on the excess glycogen in the liver.