Which syndrome is related to hepatic causes of jaundice?

Crigler-Najjar syndrome is a genetic disorder that directly affects the metabolism of bilirubin in the liver, leading to unconjugated hyperbilirubinemia and resulting jaundice. This condition is due to a deficiency of the enzyme UDP-glucuronosyltransferase (UGT), which is essential for the conjugation of bilirubin. In individuals with Crigler-Najjar syndrome, the liver's inability to process bilirubin efficiently causes an accumulation of unconjugated bilirubin in the bloodstream, manifesting as jaundice.

The other conditions listed, while they can cause jaundice, involve different mechanisms that may not be classified strictly as hepatic causes. For instance, Wilson's disease involves the accumulation of copper in the liver, leading to hepatic dysfunction, but it also affects other organs. Hereditary spherocytosis is primarily a membrane defect in red blood cells that leads to hemolysis rather than a direct liver dysfunction. Hemochromatosis involves iron overload, affecting multiple organ systems, including the liver, but again, it is not primarily a disorder of bilirubin metabolism like Crigler-Najjar syndrome.

Thus, Crigler-Najjar syndrome stands out as the condition most directly related to hepatic